Why estrogen excess is realted to lipofuscin:
“Partly, this might be because estrogen is a powerful stimulant of iron absorption, and iron is involved in the peroxidation that produces the pigment.” “But low oxygen concentration is what causes the iron to to become active in peroxidation, and estrogen acts in several ways to decrease the availability of oxygen. It appeared, therefore, that many features of aging resembled an estrogen excess, rather than estrogen deficiency.” -Ray Peat
“Partly, this might be because estrogen is a powerful stimulant of iron absorption, and iron is involved in the peroxidation that produces the pigment.” “But low oxygen concentration is what causes the iron to to become active in peroxidation, and estrogen acts in several ways to decrease the availability of oxygen. It appeared, therefore, that many features of aging resembled an estrogen excess, rather than estrogen deficiency.” -Ray Peat
